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KMID : 0869619940110040250
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Journal of Korean Society of Hospital Pharmacists
1994 Volume.11 No. 4 p.250 ~ p.254
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Dissolution rate and Content uniformity of Loperamide hydrochloride capsules
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Abstract
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Drug effect is depend on bioavailability of preparation and also bioavailability is largely depend on dissolution rate. This study was attempted to evaluate bioavailability of preparations for drug choice among many preparations by the dissolution test and content uniformity test of commercial loperamide hydrochloride capsules. The dissolution test was conducted in artificial gastrie juice, artificial intestinal juice and dissolution medium(KP Ⅵ) using Basket method with four loperamide hydrochloride preparations(A, B, C, D) which were pharmaceutically equivalent. The results were as follows : 1) The dissolution rate in artifitial intestinal juice and dissolution medium was higher in order of four different brands D > A > C > B. 2) Content uniformity of four different brands was better in such order as A > D > C > B.
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